Abnormal sarcoplasmic reticulum Ca2+activity and uptake in human heart failure
نویسندگان
چکیده
منابع مشابه
Targeting Sarcoplasmic Reticulum Ca Uptake to Improve Heart Failure
The association between disturbed Ca 2 handling within cardiac myocytes and heart failure has been established in many studies of human myocardium from patients with end-stage heart failure undergoing heart transplantation.1–3 The causality is more difficult to prove at this late time point.4 Yet, the observed reduction in the Ca available for myofilament activation and reduced Ca reuptake in t...
متن کاملSarcoplasmic Reticulum Ca Homeostasis and Heart Failure
Heart function vitally relies on precisely controlled intracellular Ca homeostasis during each cardiac cycle. Abnormalities in Ca regulation cause contractile dysfunction and arrhythmias under different pathological conditions including heart failure (HF). Playing a particularly important role in heart contraction is the sarcoplasmic reticulum (SR). In adult ventricular myocytes, the SR forms a...
متن کاملSarcoplasmic Reticulum Calcium Uptake
To investigate the mechanism underlying postischemic cardiac dysfunction (myocardial stunning), contractility and adenine nucleotide metabolism were studied in three groups of isolated perfused rabbit hearts (control, ischemic, and reperfused), whereas Ca2` uptake by the sarcoplasmic reticulum (SR) was measured in homogenates obtained from them. The hearts were Langendorff-perfused under consta...
متن کاملAbnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure.
OBJECTIVE In heart failure, little information is available as to the Ca2+ release function of sarcoplasmic reticulum (SR), which plays a major role in cardiac contractile function. Here, we assessed the rapid kinetics of drug-induced Ca2+ release from cardiac SR in combination with a measurement of ryanodine binding in heart failure. METHODS The SR vesicles were isolated from dog left ventri...
متن کاملSarcoplasmic reticulum Ca-ATPase and heart failure 20 years later.
T his article reflects on the impact of a classic paper identifying the effects of loss of sarcoplasmic reticu-lum Ca-ATPase activity in heart failure. Understanding the effects of heart failure on contraction and Ca signaling in the heart has long been a priority. By the late 1980s, many studies on animal models had shown that heart failure resulted in a slowing of the decay of the systolic Ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1996
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(96)80419-0